Search Results for: USC

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

The article “Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response” by Yasuhiro Fujioka, Yuko Noda, Atsushi Noda, Yukari Yamasaki, Rika Hayakawa, Kazuaki Okada, Takeshi Iwatsubo, Yoshinori Watanabe, and Nobuo N. Noda is a landmark contribution to molecular biology. Their work uncovers a novel redox-independent mechanism for NRF2 activation through ULK1-mediated phosphorylation … Continue reading Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

Mechanism for Vipp 1 spiral formation, ring biogenesis, and membrane repair

The ESCRT-III-like protein Vipp1 couples filament polymerization with membrane remodeling. It assembles planar sheets as well as 3D rings and helical polymers, all implicated in mitigating plastid-associated membrane stress. The architecture of Vipp1 planar sheets and helical polymers remains unknown, as do the geometric changes required to transition between polymeric forms. * In the article … Continue reading Mechanism for Vipp 1 spiral formation, ring biogenesis, and membrane repair

Real-time multistep asymmetrical disassembly of nucleosomes and chromatosomes visualized by high-speed atomic force microscopy

During replication, expression, and repair of the eukaryotic genome, cellular machinery must access the DNA wrapped around histone proteins forming nucleosomes. These octameric protein·DNA complexes are modular, dynamic, and flexible and unwrap or disassemble either spontaneously or by the action of molecular motors. Thus, the mechanism of formation and regulation of subnucleosomal intermediates has gained … Continue reading Real-time multistep asymmetrical disassembly of nucleosomes and chromatosomes visualized by high-speed atomic force microscopy