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Watching Designed Proteins Assemble with High-Speed AFM

How the surface beneath a protein can influence the structures it forms What determines whether nanoscale building blocks assemble into an ordered structure or remain disordered? In a study published in Nature Communications, Sakshi Yadav Schmid and colleagues investigated this question using designed protein nanorods at liquid–solid interfaces. Combining high-speed atomic force microscopy (HS-AFM), machine-learning … Continue reading Watching Designed Proteins Assemble with High-Speed AFM

DNA Origami Nanovaccine Demonstrates Full Protection Against SARS-CoV-2 in Mice

A study recently published in Communications Biology (Nature Portfolio) by Esra Oktay, Farhang Alem, Keziah Hernandez, Michael Girgis, Christopher Green, Divita Mathur, Igor L. Medintz, Aarthi Narayanan, and Rémí Veneziano introduces an innovative DNA origami–based nanovaccine platform targeting the receptor-binding domain (RBD) of SARS-CoV-2. Their findings highlight the potential of rationally engineered DNA nanoparticles to … Continue reading DNA Origami Nanovaccine Demonstrates Full Protection Against SARS-CoV-2 in Mice

Decoding the Ubiquitin Code: How the RQT Complex Clears Colliding Ribosomes

Matsuo et al., recently published a landmark study in Nature Communications (vol. 14, article 79, Jan 10 2023). , looking at how cells recognize and resolve ribosome collisions—a critical event in obeying translational fidelity and avoiding protein quality control failure. The researchers employed a combination of molecular genetics, biochemical assays, ubiquitin-binding studies, and advanced imaging. Key steps included mutational … Continue reading Decoding the Ubiquitin Code: How the RQT Complex Clears Colliding Ribosomes