Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films

Boron doped diamond (BDD) has great potential in electrical, and electrochemical sensing applications. The growth parameters, substrates, and synthesis method play a vital role in the preparation of semiconducting BDD to metallic BDD. Doping of other elements along with boron (B) into diamond demonstrated improved efficacy of B doping and exceptional properties.*

In the article “Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films” Srinivasu Kunuku, Mateusz Ficek, Aleksandra Wieloszynska, Magdalena Tamulewicz-Szwajkowska, Krzysztof Gajewski, Miroslaw Sawczak, Aneta Lewkowicz, Jacek Ryl, Tedor Gotszalk and Robert Bogdanowicz describe how B and nitrogen (N) co-doped diamond has been synthesized on single crystalline diamond (SCD) IIa and SCD Ib substrates in a microwave plasma-assisted chemical vapor deposition process.*

The surface topography of the CVD diamond layers was investigated using atomic force microscopy (AFM), and Kelvin probe force microscopy (KPFM) was employed to measure the contact potential difference (CPD) to calculate the work function of these CVD diamond layers.*

Atomic force microscopy topography depicted the flat and smooth surface with low surface roughness for low B doping, whereas surface features like hillock structures and un-epitaxial diamond crystals with high surface roughness were observed for high B doping concentrations. KPFM measurements revealed that the work function (4.74–4.94 eV) has not varied significantly for CVD diamond synthesized with different B/C concentrations.*

NanoWorld ARROW-EFM conductive platinumirdidium5 coated AFM probes with a typical spring constant of 2.8 N/m and a typical resonant frequency of 75 kHz were used.*

Figure 2 from “Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films “ by Srinivasu Kunuku et al: AFM topography of B/N co-doped CVD diamond on (with fixed N/C = 0.02) SCD IIa; (a) B/C ∼ 2500 ppm (b) B/C ∼ 5000 ppm (c) B/C ∼ 7500 ppm, and KPFM CPD images of B/N co-doped CVD diamond (with fixed N/C = 0.02) on SCD IIa; (d) B/C ∼ 2500 ppm (e) B/C ∼ 5000 ppm (f) B/C ∼ 7500 ppm. NanoWorld Arrow-EFM platinumiridium coated AFM probes were used for the KPFM and surface topography measurements.
Figure 2 from “Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films “ by Srinivasu Kunuku et al:
AFM topography of B/N co-doped CVD diamond on (with fixed N/C = 0.02) SCD IIa; (a) B/C ∼ 2500 ppm (b) B/C ∼ 5000 ppm (c) B/C ∼ 7500 ppm, and KPFM CPD images of B/N co-doped CVD diamond (with fixed N/C = 0.02) on SCD IIa; (d) B/C ∼ 2500 ppm (e) B/C ∼ 5000 ppm (f) B/C ∼ 7500 ppm.

*Srinivasu Kunuku, Mateusz Ficek, Aleksandra Wieloszynska, Magdalena Tamulewicz-Szwajkowska, Krzysztof Gajewski, Miroslaw Sawczak, Aneta Lewkowicz, Jacek Ryl, Tedor Gotszalk and Robert Bogdanowicz
Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films
Nanotechnology (2022),  33 125603
DOI: https://doi.org/10.1088/1361-6528/ac4130

Please follow this external link to read the full article: https://doi.org/10.1088/1361-6528/ac4130

Open Access The article “Influence of B/N co-doping on electrical and photoluminescence properties of CVD grown homoepitaxial diamond films” by Srinivasu Kunuku, Mateusz Ficek, Aleksandra Wieloszynska, Magdalena Tamulewicz-Szwajkowska, Krzysztof Gajewski, Miroslaw Sawczak, Aneta Lewkowicz, Jacek Ryl, Tedor Gotszalk and Robert Bogdanowicz is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation

Atomic Force Microscopy ( AFM ) can be utilized to determine the mechanical properties of tumor tissues in different kinds of cancers, for example breast cancer, liver cancer and lung cancer.

Oral squamous cell carcinoma (OSCC) is a common subtype of head and neck and other malignant tumors that occurs in increasing numbers. It is therefore important to learn more about the biological factors connected with the early diagnosis and treatment of OSCC. *

The human trophoblast cell surface antigen 2 (TROP2), which is also called tumor-associated calcium signal transduction-2 (TACSTD-2), is a surface glycoprotein encoded by TACSTD. *

Among the various biochemical mechanisms involved in tumorigenesis, the role of β-catenin has been studied extensively. This has shed light on the biological functions of TROP2 and its use as a prognostic biomarker for OSCC. *

TROP2 regulates tumorigenic properties including cancer cell adhesion, invasion, and migration and is overexpressed in many human cancers. Inhibiting TROP2 expression has shown promise in clinical applications. *

In the article “Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation” Baoping Zhang, Shuting Gao, Ruiping Li, Yiting Li, Rui Cao, Jingyang Cheng, Yumeng Guo, Errui Wang, Ying Huang and Kailiang Zhang investigate the role of TROP2 in OSCC patients using a combination of biophysical approaches including atomic force microscopy. *

The authors demonstrate the tissue morphology and mechanics of OSCC samples during tumor development using NanoWorld Pointprobe® CONTR AFM probes for the Atomic Force Microscopy described in the article and they believe that their findings will help develop TROP2 in accurately diagnosing OSCC in tumors with different grades of differentiation. *

Figure 5 from Baoping Zhang et al. “Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation”:
Surface morphology of OSCC tissue sections via AFM detection, irregular morphology appeared in the low differentiation
NanoWorld Pointprobe CONTR AFM probes were used for the Atomic Force Microscopy
Figure 5 from Baoping Zhang et al. “Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation”:
Surface morphology of OSCC tissue sections via AFM detection, irregular morphology appeared in the low differentiation

*Baoping Zhang, Shuting Gao, Ruiping Li, Yiting Li, Rui Cao, Jingyang Cheng, Yumeng Guo, Errui Wang, Ying Huang and Kailiang Zhang
Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation
BMC Cancer volume 20, Article number: 815 (2020)
DOI: https://doi.org/10.1186/s12885-020-07257-7

Please follow this external link to read the whole article: https://rdcu.be/cfC9G

Open Access : The article “Tissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation” by Baoping Zhang, Shuting Gao, Ruiping Li, Yiting Li, Rui Cao, Jingyang Cheng, Yumeng Guo, Errui Wang, Ying Huang and Kailiang Zhang is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.