Search Results for: USC

DNA Origami Nanovaccine Demonstrates Full Protection Against SARS-CoV-2 in Mice

A study recently published in Communications Biology (Nature Portfolio) by Esra Oktay, Farhang Alem, Keziah Hernandez, Michael Girgis, Christopher Green, Divita Mathur, Igor L. Medintz, Aarthi Narayanan, and Rémí Veneziano introduces an innovative DNA origami–based nanovaccine platform targeting the receptor-binding domain (RBD) of SARS-CoV-2. Their findings highlight the potential of rationally engineered DNA nanoparticles to … Continue reading DNA Origami Nanovaccine Demonstrates Full Protection Against SARS-CoV-2 in Mice

Decoding the Ubiquitin Code: How the RQT Complex Clears Colliding Ribosomes

Matsuo et al., recently published a landmark study in Nature Communications (vol. 14, article 79, Jan 10 2023). , looking at how cells recognize and resolve ribosome collisions—a critical event in obeying translational fidelity and avoiding protein quality control failure. The researchers employed a combination of molecular genetics, biochemical assays, ubiquitin-binding studies, and advanced imaging. Key steps included mutational … Continue reading Decoding the Ubiquitin Code: How the RQT Complex Clears Colliding Ribosomes

Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response

The article “Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response” by Yasuhiro Fujioka, Yuko Noda, Atsushi Noda, Yukari Yamasaki, Rika Hayakawa, Kazuaki Okada, Takeshi Iwatsubo, Yoshinori Watanabe, and Nobuo N. Noda is a landmark contribution to molecular biology. Their work uncovers a novel redox-independent mechanism for NRF2 activation through ULK1-mediated phosphorylation … Continue reading Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response