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Correlation of membrane protein conformational and functional dynamics

Membrane proteins (MPs) reside in the plasma membrane and perform various biological processes including ion transport, substrate transport, and signal transduction.* Function-related conformational changes in membrane proteins occur in times scales ranging from nanoseconds to seconds.* Obtaining time-resolved dynamic information of MPs in their membrane environment is still a major challenge.* Although High Speed Atomic … Continue reading Correlation of membrane protein conformational and functional dynamics

HS-AFM video of Covid’s Docking Method

Johannes Kepler University in Linz Austria has published a High-Speed Atomic Force Microscopy video of human lectin CLEC4G binding to glycans on a SARS-CoV-2 spike. This video was recorded by Daniel Canena and Peter Hinterdorfer and is, according to the two researchers, the first short film of the active structure the virus uses to attach … Continue reading HS-AFM video of Covid’s Docking Method

High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action

The current pandemic is not the only health threat worldwide. Another worry is the increasing antibiotic resistance which increases the fear to run out of effective antibiotics. This is one of the reasons why antimicrobial peptides (AMPs) are gaining more and more interest. The lipopeptide Daptomycin ( DAP ) has been therapeutically used as a … Continue reading High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action