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IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

Mucosal immunoglobulins comprise mainly secretory IgA antibodies (SIgAs), which are the major contributor to pathogen-specific immune responses in mucosal tissues. SIgAs exist as mainly dimers and tetramers and play critical roles in mucosal immune responses against influenza.* Detailed characterization of these anti-viral SIgA is important for better understanding of the mechanisms underlying anti-viral immunity.* In … Continue reading IgA tetramerization improves target breadth but not peak potency of functionality of anti-influenza virus broadly neutralizing antibody

NanoWorld™ appoints NanoAndMore Japan as a distributor for Japan

In a further move to extend its worldwide network of distribution partners NanoWorld™ today has appointed the recently founded NanoAndMore Japan KK (NanoAndMore ジャパン ) as a distributor of its line of probes for Atomic Force Microscopy (AFM) and Scanning Probe Microscopy (SPM) in Japan. NanoAndMore Japan will keep a large stock of NanoWorld AFM … Continue reading NanoWorld™ appoints NanoAndMore Japan as a distributor for Japan

High-speed AFM height spectroscopy reveals microsecond-dynamics of unlabeled biomolecules

In their recent publication “High-speed AFM height spectroscopy reveals μs-dynamics of unlabeled biomolecules” in Nature Communications George R. Heath and Simon Sheuring develop and apply HS-AFM height spectroscopy (HS-AFM-HS, a technique inspired by fluorescence spectroscopy), a technique whereby the AFM tip is held at a fixed x–y position and  the height fluctuations under the tip … Continue reading High-speed AFM height spectroscopy reveals microsecond-dynamics of unlabeled biomolecules