These findings shed light on the peculiar mechano-electrical surface properties of pathological A\u03b2 fibrils that exceed those of normal body components.*<\/p>\n
Both KPFM and nanoindentation measurements were performed using a chemically inert conductive diamond AFM tip. (NanoWorld Pointprobe<\/a> CDT-FMR<\/a>).<\/p>\n Vertical and lateral PFM images of A\u03b2 fibrils were obtained by scanning probe microscopy with a platinum\/iridium-coated silicon cantilever ( NanoWorld Pointprobe\u00ae<\/a> CONTPt<\/a> ). The scanning angle of the PFM cantilever was set to zero, with scan rate of 0.5 Hz and loading force of 10 nN. This setup minimized electrostatic contributions to the torsional movement of the tip, allowing measurements to focus on the shear electromechanical effects of A\u03b2 fibrils. Vertical and lateral drive frequencies were 53 kHz and 309 kHz, respectively.*<\/p>\n *Jinhyeong Jang, Soyun Joo, Jiwon Yeom, Yonghan Jo, Jingshu Zhang, Seungbum Hong and Chan Beum Park Open Access The article \u201cLateral Piezoelectricity of Alzheimer\u2018s A\u03b2 Aggregates<\/em>\u201d byJinhyeong Jang, Soyun Joo, Jiwon Yeom, Yonghan Jo, Jingshu Zhang, Seungbum Hong and Chan Beum Park is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article\u2019s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article\u2019s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http:\/\/creativecommons.org\/licenses\/by\/4.0\/.<\/p>\n","protected":false},"excerpt":{"rendered":" Alzheimer’s disease (AD) is the most frequent neurodegenerative disorder in the elderly aged over 65.* The extracellular accumulation of beta-amyloid (A\u03b2) aggregates in the brain is considered as the major event worsening the AD symptoms, but its underlying reason has remained unclear. In the article \u201eLateral Piezoelectricity of Alzheimer\u2018s A\u03b2 Aggregates\u201c by Jinhyeong Jang, Soyun … Continue reading Lateral Piezoelectricity of Alzheimer\u2018s A\u03b2 Aggregates<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[790,954,66,65,228,949,948,947,950,951,36,35,935,867,340,339,955,251,80,952,169,81,936,474,473,580,519,953,513,514,515,729,795],"class_list":{"0":"post-2827","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"hentry","6":"category-news","7":"tag-afm-nanoindentation","8":"tag-afm-","9":"tag-afm","12":"tag-alzheimer","13":"tag-alzheimers","14":"tag-alzheimers-disease","15":"tag-beta-amyloid","16":"tag-cdt-fmr","17":"tag-conductive-afm-tip","18":"tag-conductive-diamond-coated-afm-tip","19":"tag-contpt","20":"tag-force-curves","21":"tag-kelvin-probe-force-microscopy","22":"tag-kpfm","23":"tag-lateral-piezoelectricity","24":"tag-nanoindentation","25":"tag-pfm","26":"tag-piezoelectric-characteristics","27":"tag-piezoelectricity","28":"tag-piezoresponse-force-microscopy","29":"tag-pointprobe-contpt","30":"tag-vector-pfm","31":"tag-vector-piezoresponse-force-microscopy","32":"tag-youngs-modulus","33":"tag-519","34":"tag-953","35":"tag-513","36":"tag--kpfm","37":"tag-515","38":"tag-729","39":"tag-795"},"_links":{"self":[{"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/posts\/2827","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/comments?post=2827"}],"version-history":[{"count":15,"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/posts\/2827\/revisions"}],"predecessor-version":[{"id":2862,"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/posts\/2827\/revisions\/2862"}],"wp:attachment":[{"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/media?parent=2827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/categories?post=2827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nanoworld.com\/blog\/wp-json\/wp\/v2\/tags?post=2827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/www.nanoworld.com\/blog\/wp-content\/uploads\/2024\/11\/IMG_0408.jpeg\")
<\/a>
Nanoindentation test result of A\u03b2 fibrils. Direct piezoelectric effects are tested by measuring the surface potential change before and after nano-indentation of A\u03b2 fibrils.
(A) Schematic illustration of the nanoindentation test for A\u03b2 fibrils coated on an Au\/Cr substrate.
(B) Topgraphy of A\u03b2 fibrils acquired before and after applying nanoindentation. The post-indentation image shows white spots resulting from physical interactions between the AFM tip and the sample, while the approximate structure of the A\u03b2 fibrils remains intact. Height and potential line sections obtained fom the (c) blue and (d) red lines are shown in the topgraphy of A\u03b2 fibrils. The height remains unchanged, while electrical voltage increment and decrement were observed at the blue and red lines, respectively.
(D) During the nanoindentation the Young\u2018s modulus of A\u03b2 – fibrils was measured to be 3.17 GPa, closely approxmating the literature (Nanoscale 4, 4426-4429 (2012). Both KPFM and nanoindentation measurements were performed using a chemically inert conductive diamond AFM tip (CDT-FMR, NanoWorld, Switzerland). Collected force curves were analyzed using the Hertz model to estimate the elastic moduli.<\/figcaption><\/figure>\n
\nLateral Piezoelectricity of Alzheimer\u2018s A\u03b2 Aggregates<\/strong>
\nAdvanced Science, Volume 11, Issue 39, October 024, 2406678
\nDOI: https:\/\/doi.org\/10.1002\/advs.202406678<\/a><\/p>\n